Perforin and hematological cancer
نویسندگان
چکیده
منابع مشابه
Perforin and hematological cancer
Rev Bras Hematol Hemoter. 2011;33(4):250-8 3. Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir ...
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Perforin gene (PRF1) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH) and in patients with lymphoma. The aim of the present study was to determine whether patients with a familial aggregation of hematological malignancies harbor germline perforin gene mutations. For this purpose, 81 unrelated families from Tunisia and F...
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Introduction The optimistic and naive view of the early l980s that mAbs2 were ‘ ‘ magic bullets’ ‘ has now been replaced by a more realistic understanding of the many obstacles to their effective use. Although some mAbs have produced significant antitumor responses in humans (1-6), a number of factors, including the weak cytotoxic activity of many murine mAbs. the difficulty in delivering mAbs ...
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tomized patients. For example, pretransplantation disease duration was somewhat longer (albeit not significantly so) in splenectomized patients, and although not the case in the present study, disease duration has been found to be inversely correlated with posttransplantation outcome for other indications. In addition, splenectomized patients tended to be older and more often received a transpl...
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Several products of CTL and NK cells, including a pore-forming protein (PFP;t perforin or cytolysin) (1-4) and several serine esterases (SE) (5-12), have been cloned and sequenced . These proteins are localized to cytoplasmic granules and represent the known structural components ofthe pore-formation and granule exocytosis models for cell-mediated killing (13-17). Granule mediators are expresse...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2011
ISSN: 1516-8484
DOI: 10.5581/1516-8484.20110070